b c An, Na; Fleming, Aaron.; White, Henry.; Burrows, Cynthia. ACS Fellow, 2010, distinguished Teaching Award, 2011, editor-in-Chief, Accounts of Chemical Research, 2014. 11 Burrows helped to discover specific DNA glycosylases that preferentially repaired oxidative damages at telomeric sites. 4, 6, one of the objectives of the Burrows Laboratory is to apply nanopore technology to identify, quantify, and analyze DNA damage brought on by oxidative stresses.
Faculty Directory for the Department of Chemistry at the University of Utah. Overview, and Section.4 introduces the remaining structure of this thesis.
David, Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hneil1, Biochemistry 2008,. Muller, "Oxidative nucleobase modifications leading to strand scission Chem. Burrows, "Sequence and stacking dependence of 8-oxoguanine oxidation: Comparison of one-electron. Singlet oxygen mechanisms. "Nanopore detection of 8-oxoguanine in the human telomere repeat sequence". A b c "Cynthia. PCR amplification and other DNA sequencing methods cannot detect DNA damage alone because their basis relies on the four classical unmodified bases: cytosine, adenine, guanine, and thymine. Burrows, Synthesis and Characterization of the Oxidized dGTP Lesions and. DNA strand passes through the a-hemolysin nanopore and allows researchers to detect single base damaged site.